{"id":8334,"date":"2022-03-17T09:34:20","date_gmt":"2022-03-17T12:34:20","guid":{"rendered":"https:\/\/higiene.edu.uy\/biologia-parasitaria\/?page_id=8334"},"modified":"2025-01-16T15:46:05","modified_gmt":"2025-01-16T18:46:05","slug":"produccion-cientifica","status":"publish","type":"page","link":"https:\/\/higiene.edu.uy\/biologia-parasitaria\/produccion-cientifica\/","title":{"rendered":"Producci\u00f3n Cient\u00edfica"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"8334\" class=\"elementor elementor-8334\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a1c96a9 elementor-section-full_width elementor-section-stretched elementor-section-height-default elementor-section-height-default\" data-id=\"a1c96a9\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0b8823f\" data-id=\"0b8823f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-afae4a0 edubin-nav-menu-breakpoint-big-tablet elementor-widget elementor-widget-edubin-header-menu\" data-id=\"afae4a0\" data-element_type=\"widget\" data-widget_type=\"edubin-header-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"edubin-nav-menu-wrapper edubin-header-area edubin-navbar-expand-lg edubin-elementor-nav-menu-wrapper\"><nav class=\"main-navigation edubin-navbar-collapse edubin-elementor-nav\"><ul id=\"menu-1-afae4a0\" class=\"edubin-navbar-nav edubin-navbar-right nav-menu edubin-nav-ul-wrapper\"><li itemscope=\"itemscope\" itemtype=\"https:\/\/www.schema.org\/SiteNavigationElement\" id=\"menu-item-8659\" class=\"menu-item menu-item-type-custom menu-item-object-custom nav-item menu-item-8659\"><a class=\"nav-link\" href=\"\/biologia-parasitaria\/\">Inicio<\/a><\/li>\n<li itemscope=\"itemscope\" itemtype=\"https:\/\/www.schema.org\/SiteNavigationElement\" id=\"menu-item-8319\" class=\"menu-item menu-item-type-custom menu-item-object-custom nav-item menu-item-8319\"><a class=\"nav-link\" href=\"\/biologia-parasitaria\/integrantes\">Integrantes<\/a><\/li>\n<li itemscope=\"itemscope\" itemtype=\"https:\/\/www.schema.org\/SiteNavigationElement\" id=\"menu-item-8585\" class=\"menu-item menu-item-type-custom menu-item-object-custom nav-item menu-item-8585\"><a class=\"nav-link\" href=\"\/biologia-parasitaria\/cursos\">Cursos<\/a><\/li>\n<li itemscope=\"itemscope\" itemtype=\"https:\/\/www.schema.org\/SiteNavigationElement\" id=\"menu-item-8586\" class=\"menu-item menu-item-type-custom menu-item-object-custom nav-item menu-item-8586\"><a class=\"nav-link\" href=\"\/biologia-parasitaria\/lineas-de-investigacion\">L\u00edneas de Investigaci\u00f3n<\/a><\/li>\n<li itemscope=\"itemscope\" itemtype=\"https:\/\/www.schema.org\/SiteNavigationElement\" id=\"menu-item-8644\" class=\"menu-item menu-item-type-custom menu-item-object-custom nav-item menu-item-8644\"><a class=\"nav-link\" href=\"\/biologia-parasitaria\/proyectos\">Proyectos<\/a><\/li>\n<li itemscope=\"itemscope\" itemtype=\"https:\/\/www.schema.org\/SiteNavigationElement\" id=\"menu-item-8582\" class=\"menu-item menu-item-type-custom menu-item-object-custom nav-item menu-item-8582\"><a class=\"nav-link\" href=\"\/biologia-parasitaria\/produccion-cientifica\">Producci\u00f3n cient\u00edfica<\/a><\/li>\n<li itemscope=\"itemscope\" itemtype=\"https:\/\/www.schema.org\/SiteNavigationElement\" id=\"menu-item-8583\" class=\"menu-item menu-item-type-custom menu-item-object-custom nav-item menu-item-8583\"><a class=\"nav-link\" href=\"\/biologia-parasitaria\/extension\">Extensi\u00f3n<\/a><\/li>\n<li itemscope=\"itemscope\" itemtype=\"https:\/\/www.schema.org\/SiteNavigationElement\" id=\"menu-item-8581\" class=\"menu-item menu-item-type-custom menu-item-object-custom nav-item menu-item-8581\"><a class=\"nav-link\" href=\"\/biologia-parasitaria\/links-de-interes\">Links de inter\u00e9s<\/a><\/li>\n<\/ul><\/nav><div class=\"edubin-default-header-mobile-navbar edubin-mobile-menu\"><div class=\"edubin-elementor-mobile-menu-overlay\"><\/div><div class=\"edubin-elementor-mobile-hamburger-menu\"><a href=\"javascript:void(0);\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" id=\"Capa_1\" x=\"0px\" y=\"0px\" viewBox=\"0 0 448 512\" style=\"enable-background:new 0 0 448 512;\" xml:space=\"preserve\"><style type=\"text\/css\">\t.st0{fill:#FFFFFF;}<\/style><path class=\"st0\" d=\"M0,96c0-17.7,14.3-32,32-32h384c17.7,0,32,14.3,32,32s-14.3,32-32,32H32C14.3,128,0,113.7,0,96z M0,256 c0-17.7,14.3-32,32-32h384c17.7,0,32,14.3,32,32s-14.3,32-32,32H32C14.3,288,0,273.7,0,256z M448,416c0,17.7-14.3,32-32,32H32 c-17.7,0-32-14.3-32-32s14.3-32,32-32h384C433.7,384,448,398.3,448,416z\"><\/path><\/svg><\/a><\/div><div class=\"edubin-mobile-menu-nav-wrapper edubin-elementor-mobile-menu-nav-wrapper\"><div class=\"edubin-elementor-mobile-menu-close\"><a href=\"javascript:void(0);\"><i aria-hidden=\"true\" class=\"flaticon-cancel\"><\/i><\/a><\/div><ul id=\"edubin-elementor-mobile-menu-item\" class=\"edubin-elementor-mobile-menu-item\"><li itemscope=\"itemscope\" itemtype=\"https:\/\/www.schema.org\/SiteNavigationElement\" class=\"menu-item menu-item-type-custom menu-item-object-custom nav-item menu-item-8659\"><a class=\"nav-link\" href=\"\/biologia-parasitaria\/\">Inicio<\/a><\/li>\n<li itemscope=\"itemscope\" itemtype=\"https:\/\/www.schema.org\/SiteNavigationElement\" class=\"menu-item menu-item-type-custom menu-item-object-custom nav-item menu-item-8319\"><a class=\"nav-link\" href=\"\/biologia-parasitaria\/integrantes\">Integrantes<\/a><\/li>\n<li itemscope=\"itemscope\" itemtype=\"https:\/\/www.schema.org\/SiteNavigationElement\" class=\"menu-item menu-item-type-custom menu-item-object-custom nav-item menu-item-8585\"><a class=\"nav-link\" href=\"\/biologia-parasitaria\/cursos\">Cursos<\/a><\/li>\n<li itemscope=\"itemscope\" itemtype=\"https:\/\/www.schema.org\/SiteNavigationElement\" class=\"menu-item menu-item-type-custom menu-item-object-custom nav-item menu-item-8586\"><a class=\"nav-link\" href=\"\/biologia-parasitaria\/lineas-de-investigacion\">L\u00edneas de Investigaci\u00f3n<\/a><\/li>\n<li itemscope=\"itemscope\" itemtype=\"https:\/\/www.schema.org\/SiteNavigationElement\" class=\"menu-item menu-item-type-custom menu-item-object-custom nav-item menu-item-8644\"><a class=\"nav-link\" href=\"\/biologia-parasitaria\/proyectos\">Proyectos<\/a><\/li>\n<li itemscope=\"itemscope\" itemtype=\"https:\/\/www.schema.org\/SiteNavigationElement\" class=\"menu-item menu-item-type-custom menu-item-object-custom nav-item menu-item-8582\"><a class=\"nav-link\" href=\"\/biologia-parasitaria\/produccion-cientifica\">Producci\u00f3n cient\u00edfica<\/a><\/li>\n<li itemscope=\"itemscope\" itemtype=\"https:\/\/www.schema.org\/SiteNavigationElement\" class=\"menu-item menu-item-type-custom menu-item-object-custom nav-item menu-item-8583\"><a class=\"nav-link\" href=\"\/biologia-parasitaria\/extension\">Extensi\u00f3n<\/a><\/li>\n<li itemscope=\"itemscope\" itemtype=\"https:\/\/www.schema.org\/SiteNavigationElement\" class=\"menu-item menu-item-type-custom menu-item-object-custom nav-item menu-item-8581\"><a class=\"nav-link\" href=\"\/biologia-parasitaria\/links-de-interes\">Links de inter\u00e9s<\/a><\/li>\n<\/ul><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dc6dc8d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dc6dc8d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f49a0c8\" data-id=\"f49a0c8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-05999d7 elementor-widget elementor-widget-spacer\" data-id=\"05999d7\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-474e3a9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"474e3a9\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-dfab3fd\" data-id=\"dfab3fd\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6c244be elementor-widget elementor-widget-custom-title-addons\" data-id=\"6c244be\" data-element_type=\"widget\" data-widget_type=\"custom-title-addons.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"tpc-double_heading\"><div class=\"dbl__subtitle\"><span>PRODUCCI\u00d3N CIENT\u00cdFICA<\/span><\/div><h3 class=\"dbl__title-wrapper\"><span class=\"dbl__title dbl-title_1\">Unidad Acad\u00e9mica Laboratorio de Biolog\u00eda Parasitaria<\/span><\/h3><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3e55bbf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3e55bbf\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-297ef02\" data-id=\"297ef02\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a4a849d elementor-widget elementor-widget-spacer\" data-id=\"a4a849d\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d38f86a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d38f86a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8520a7a\" data-id=\"8520a7a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9d2761c elementor-widget elementor-widget-heading\" data-id=\"9d2761c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Publicaciones Recientes\n<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-68970c1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"68970c1\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4124b16\" data-id=\"4124b16\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9569836 elementor-widget elementor-widget-text-editor\" data-id=\"9569836\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Di Maggio LS, Tirloni L, Uhl M, Carmona C, Logullo C, Mulenga A, da Silva Vaz I Jr , Berasain B. Serpins in Fasciola hepatica: insights into host-parasite interactions. Int J Parasitol (2020), 50(12):931-943. doi: 10.1016\/j.ijpara.2020.05.010<\/p><p>Cancela M and Maggioli G. Cloning and heterologous expression of protein-coding sequences in Escherichia coli. Methods Mol Biol (2020), 2137:51-66. doi: 10.1007\/978-1-0716-0475-5_5<\/p><p>Maggioli G, Salazar C, Fossa F and Carmona C. Liver fluke vaccine assessment in cattle. Methods Mol Biol (2020), 2137:205-212. doi: 10.1007\/978-1-0716-0475-5_15<\/p><p>Salazar C, Tort JF and Carmona C. Design of a peptide\u2013carrier vaccine based on the highly immunogenic Fasciola hepatica leucine aminopeptidase. Methods Mol Biol (2020), 2137:205-212. doi: 10.1007\/978-1-0716-0475-5_14.<\/p><p>Di Maggio LS, Tirloni L, Pinto AFM, Diedrich JK, Yates JR 3rd, Carmona C, Berasain P, da Silva Vaz I Jr. A proteomic comparison of excretion\/secretion products in Fasciola hepatica newly excysted juveniles (NEJ) derived from Lymnaea viatrix or Pseudosuccinea columella. Exp Parasitol (2019), 201:11-20. doi: 10.1016\/j.exppara.2019.04.004.<\/p><p>Dominguez MF, Gonz\u00e1lez-Miguel J, Carmona C, Dalton JP, Cwiklinski K, Tort J, Siles-Lucas. Low allelic diversity in vaccine candidates genes from different locations sustain hope for Fasciola hepatica immunization. M Vet Parasitol (2018), 15;258:46-52. doi: 10.1016\/j.vetpar.2018.06.011.<\/p><p>Maggioli G, Rinaldi G, Giaudrone I, Berasain P, Tort JF, Brindley PJ, Carmona C. Expression, purification and characterization of two leucine aminopeptidases of the blood fluke, Schistosoma mansoni. Molecular &amp; Biochemical Parasitology (2018). 219, 17-23. doi.org\/10.1016\/j.molbiopara.2017.11.006.<\/p><p>McNulty SN, Tort JF, Rinaldi G, Fischer K, Rosa BA, Smircich P, Fontenla S, Choi YJ, Tyagi R, Hallsworth-Pepin K, Mann VH, Kammili L, Latham PS, Dell\u2019Oca N, Dominguez F, Carmona C, Fischer PU, Brindley PJ, Mitreva. Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers. M PLoS Genet (2017), 13(1):e1006537. doi: 10.1371\/journal.pgen.1006537.<\/p><p>Noya V, Brossard N, Rodr\u00edguez E, Dergan-Dylon LS, Carmona C, Rabinovich GA, Freire T. A mucin-like peptide from Fasciola hepatica instructs dendritic cells with parasite specific Th1-polarizing activity. Sci Rep (2017), 7:40615. doi: 10.1038\/srep40615.<\/p><p>Di Maggio LS, Tirloni L, Pinto AF, Diedrich JK, Yates Iii JR, Benavides U, Carmona C, da Silva Vaz I Jr, Berasain. Across intra-mammalian stages of the liver fluke Fasciola hepatica: a proteomic study. P Sci Rep (2016), 6:32796. doi: 10.1038\/srep32796.<\/p><p>Maggioli G, Bottini G, Basika T, Alonzo P, Salinas G, Carmona C. Immunization with Fasciola hepatica thioredoxin glutathione reductase failed to confer protection against fasciolosis in cattle. Veterinary Parasitology (2016), doi:10.1016\/j.vetpar.2016.05.007.<\/p><p>Noya V, Brossard N, Berasa\u00edn P, Rodr\u00edguez E, Chiale C, Mazal D, Carmona C, Freire T. A mucin-like peptide from Fasciola hepatica induces parasite-specific Th1-type cell immunity. Parasitol Res (2016), 115(3):1053-63. doi: 10.1007\/s00436-015-4834-z.<\/p><p>Cancela M, Santos GB, Carmona C, Ferreira HB, Tort JF, Zaha A. Fasciola hepatica mucin-encoding gene: expression, variability and its potential relevance in host-parasite relationship. Parasitology (2015), 142(14):1673-81. doi: 10.1017\/S0031182015001134.<\/p><p>Rodr\u00edguez E, Noya V, Cervi L, Chiribao ML, Brossard N, Chiale C, Carmona C, Giacomini C, Freire T. Glycans from Fasciola hepatica Modulate the Host Immune Response and TLR-Induced Maturation of Dendritic Cells. PLoS Negl Trop Dis (2015), 9(12):e0004234. doi: 10.1371\/journal.pntd.0004234.<\/p><p>Ross F, Hern\u00e1ndez P, Porcal W, L\u00f3pez GV, Cerecetto H, Gonz\u00e1lez M, Basika T, Carmona C, Maggioli G, Bonilla M, Gladyshev VG, Boiani M, Salinas G. Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites. PLoS ONE (2012), 7(4): e35033. doi:10.1371\/journal.pone.0035033.<\/p><p>Maggioli G, Acosta D, Silveira F, Rossi S, Giacaman S, Basika T, Gayo V, Rosadilla D, Roche L, Tort J, Carmona C. rFhLAP, a recombinant gut-associated M17 leucine aminopeptidase confers high level of protection against Fasciola hepatica infection in sheep using different adjuvants. Vaccine (2011), 29:9057-9063.<\/p><p>Maggioli G, Silveira F, Mart\u00edn-Alonso JM, Salinas G, Carmona C, Parra F. A recombinant thioredoxin-glutathione reductase from Fasciola hepatica induces a protective response in rabbits. Experimental Parasitology (2011), 129:323-330.<\/p><p>Cancela M, Ru\u00e9talo N, Dell\u2019Oca N, da Silva E, Smircich P, Rinaldi G, Roche L, Carmona C, Alvarez-Val\u00edn F, Zaha A, Tort JF. Survey of transcripts expressed by the invasive juvenile stage of the liver fluke Fasciola hepatica. BMC Genomics (2010), 11:227. doi: 10.1186\/1471-2164-11-227.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-02a8d5d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"02a8d5d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8ff1bba\" data-id=\"8ff1bba\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-16bab35 elementor-widget elementor-widget-heading\" data-id=\"16bab35\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Publicaciones Anteriores<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-64cb7e8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"64cb7e8\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d6fd2f4\" data-id=\"d6fd2f4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3b7a716 elementor-widget elementor-widget-text-editor\" data-id=\"3b7a716\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Carmona, C.; Smith, A.; Dowd, A.; Dalton, J. (1993)\u00a0<em>Fasciola hepatica<\/em>: a cathepsin L prevents antibody-mediated eosinophil adherence to newly excysted juveniles. Molecular and Biochemical Parasitology 62, 9.<\/p><p>Carmona, C., Smith, A., Dowd, A., Acosta, D., Dalton, J. (1994) Neutralization of\u00a0<em>Fasciola hepatica<\/em>\u00a0cathepsin L by anti-cathepsin L antibodies. Parasite Immunology 16, 235.<\/p><p>Carmona, C.; Mc. Gonicle, M.; Dalton, J. (1994) A novel dipeptidyl peptidase is secreted by\u00a0<em>Fasciola hepatica<\/em>. Parasitology 109, 113.<\/p><p>Dalton, J.; Dowd, A.; Carmona, C. (1994) The cathepsin L proteinases secreted by the parasite trematode\u00a0<em>Fasciola hepatica<\/em>. In: Biology of Parasitism (Erlich, R. and NIeto, A. eds.), pp. 1-15 Ed Trilce, Montevideo.<\/p><p>Sakai, H., Malgor, R., Basmadjian, I., Oku, Y., Kamiya, M. and Carmona, C. (1995) An enzyme-linked immunosorbent assay (ELISA) for the detection of\u00a0<em>Echinococcus granulosus<\/em>\u00a0coproantigens in dogs. Japanese Journal of Parasitology 44. 694-699.<\/p><p>Calegari, L., Gezuele, E., Torres, E., Carmona, C. (1996) Botryomycosis produced by\u00a0<em>Pseudomonas vesicularis<\/em>. International Journal of Dermatology 35, 817-818.<\/p><p>Sato, H., Kamiya, H., Grauert, M.R., Stern, D., Altamirano, Z., Perdomo, R., Carb\u00f3, A., Alvarez, C., Monti, J. Kamiya, M., C. Carmona.\u00a0(1996) Comparison of serodiagnostic tests and ultrasonography for cystic hydatidosis in an epidemiological study of rural Uruguay. Journal of Parasitology 82, 852-854.<\/p><p>Carb\u00f3, A.,m Yodzis, S., Carter, F., Monti, J., Carmona, C., Alvarez, C., Lloyd, S., Gemmel, M., Tiscornia, E., Yarz\u00e1bal, L., Perdomo. R. Clasificaci\u00f3n de las im\u00e1genes ecogr\u00e1ficas de la equinococosis hepatica. S\u00edntesis 6, 111-116.<\/p><p>Berasa\u00edn, P., Go\u00f1\u00ed, F., Mc.Gonicle, S., Dowd, A., Dalton, J., Frangione, B., Carmona, C. (1997) Proteinases secreted by\u00a0<em>Fasciola hepatica<\/em>\u00a0degrade extracelullar matrix and basement membrane components.\u00a0Journal of Parasitology 83, 1-5.<\/p><p>Perdomo, R., Alvarez, C., Monti, J., Ferreira, C., Chiesa, A., Carb\u00f3, A., Alvez, R., Grauert, R., Stern, D., Carmona, C. (1997) Principles of the surgical approach in human liver cystic echinococcosis. Acta Tropica 64, 109-122.<\/p><p>Malgor, R., Nonaka, N., Basmadjian, Y., Sakai, H., Car\u00e1mbula, B., Oku, Y., Carmona, C., Kamiya, M. (1997) Coproantigen detection in dogs experimentally and naturally infected with\u00a0<em>Echinococcus granulosus<\/em>\u00a0by a monoclonal antobody-based enzyme-linked immunosorbent assay. International Journal for Parasitology 27, 1605-1612.<\/p><p>Piacenza, L., Acosta, D., Dowd, A., McGonicle, S., Dalton, J.P., Carmona, C. (1997) Cathepsin L proteinases secreted by\u00a0<em>Fasciola hepatica<\/em>: inhibitory effect of serum from experimentally infected rabbits demonstrated by gelatin-substrate poliacrylamide gel electrophoresis. Journal of Helminthology. 71, 333-338.<\/p><p>Acosta, D., Go\u00f1i, F., Carmona, C. (1998) Characterization and partial purification of a leucine aminopeptidase from\u00a0<em>Fasciola hepatica<\/em>. Journal of Parasitology 1-7, 1998.<\/p><p>Carmona, C., Perdomo, R., Carb\u00f3, A., Alvarez, C., Monti, J., Grauert, R., Stern, D., Perera, G., Lloyd, S., Bazzini, R., Gemmell, M., Yarz\u00e1bal, L. (1998) Risk factors associated with human cystic echinococcosis in Florida, Uruguay: results of a mass screening study using ultrasound and serology. American Journal of Tropical Medicine and Hygiene. 58, 599-605.<\/p><p>Piacenza, L., Radi, R., Go\u00f1i, F., Carmona, C. (1998) CuZn superoxide dismutase activities from\u00a0<em>Fasciola hepatica<\/em>.\u00a0Parasitology 117, 555-562.<\/p><p>Carmona, C. Proteasas secretadas por\u00a0<em>Fasciola hepatica<\/em>. (1998) Bolet\u00edn de la RTPD Network, 1,0, 18-19.<\/p><p>Piacenza, L., Acosta, D., Basmadjian, I., Dalton, J.P., Carmona, C. (1999) Vaccination with cathepsin L proteinases and with leucine aminopeptidase induces high levels of protection against fascioliasis in sheep. Infection and Immunity 67, 1954-1961.<\/p><p>Berasain, P., Carmona, C., Frangione, B., Dalton, J., Go\u00f1i, F. (2000) Interaction of\u00a0<em>Fasciola hepatica<\/em>\u00a0proteases with human IgG subclasses. Basis of parasite subversion of the humoral immune response. Experimental Parasitology 94, 99-110.<\/p><p>Torgerson, P. R., Carmona, C. and Bonifacino, R. (2000) Estimating the economic effects of echinococcosis: Uruguay an upper middle income developing country.\u00a0Annals of Tropical Medicine and Parasitology, 94, 703-713.<\/p><p>Alvarez, D., Medeiros, A., M\u00edguez, M., Casaravilla, C., Malgor, R., Carmona, C., Nieto, A. Osinaga, E. (2001) O-glycosylation in\u00a0<em>Echinococcus granulosus<\/em>: Identification and characterisation of the carcinoma associated Tn antigen. Experimental Parasitology, 98, 100-109.<\/p><p>Carnevale, S., Rodr\u00edguez, M., Guarnera, E., Carmona, C., Tanos, T. Angel, S. (2001) Inmunodiagnosis of fasciolosis using recombinant procathepsin L cystein proteinase.\u00a0Diagnositic Microbiology and Infectious Disease, 41:43-49.<\/p><p>Touz, C., Nores, M., Slavin, I., Carmona, C., Conrad, J., Mowatt, M., Nash, T., Coronel., C., Lujan, H. (2002)\u00a0The activity of a develomentally regulated cysteine proteinase is required for cyst wall formation in the primitive eukaryote\u00a0<em>Giardia lamblia<\/em>.\u00a0Journal of Biological Chemistry 277, 8474 \u2013 8481.<\/p><p>Touz, C., Nores, M., Slavin, I., Piacenza, L., Acosta, D., Carmona, C., Luj\u00e1n, H. (2002)\u00a0A membrane-associated dipeptidyl peptidase IV-homolog is involved in encystation-specific gene expression during\u00a0<em>Giardia<\/em>\u00a0differentiation. The Biochemical Journal.364, 703-710.<\/p><p>Bentancor, A, Piacenza, L., Carmona, C. (2002) Immunization with cathepsin L proteinases CL1 y CL2 secreted by\u00a0<em>Fasciola hepatica<\/em>\u00a0elicit a preferential type 1 response based on IgG2a antibodies in rats.\u00a0Journal of Helminthology 76, 199-207.<\/p><p>Freire, T., Robello, C., Casaravilla, C., Medeiros, A., Carmona, C., Osinaga, E. (2002) Ant\u00edgenos muc\u00ednicos de O-glicolisaci\u00f3n simple: nuevas similitudes moleculares entre c\u00e9lulas cancerosas y par\u00e1sitos. Actas de Fisiolog\u00eda de la Facultad de Medicina, 8, 89-107.<\/p><p>Freire, T., Casaravilla, C., Carmona, C., Osinaga, E. (2003).\u00a0Mucin type\u00a0<em>O<\/em>-glycosylation in\u00a0<em>Fasciola hepatica<\/em>: characterization of carcinoma associated Tn and sialyl-Tn antigens and evaluation of UDP-GalNAc:polypeptide-acetylgalactosaminyltransferase activity.\u00a0 International\u00a0 Journal\u00a0 for\u00a0 Parasitology 33, 47-56.<\/p><p>Casaravilla, C., Malgor, R., Carmona, C. (2003)\u00a0Characterization of carbohydrates of adult\u00a0<em>Echinococcus granulosus<\/em>\u00a0by lectin binding analysis. Journal of Parasitology. 89, 57-61.<\/p><p>Berasain, P., Carmona, C., Frangione, B., Cazzulo, J.J., Go\u00f1i, F. (2003)\u00a0Specific cleavage sites on human IgG subclasses by cruzipain, the major cystine proteinase from\u00a0<em>Trypanosoma cruzi<\/em>.\u00a0Molecular and Biochemical Parasitology.<\/p><p>Casaravilla, C., Freire, T., Malgor, R., Carmona, C., Osinaga, E. (2003) Mucin-type O\u2013glycosylation in helminth parasites from major taxonomic groups: evidence for widespread distribution of the tn antigen (galnac-ser\/thr) and identification of udp-galnac:polypeptide n-acetylgalactosaminyltransferase activity. Journal of Parasitology.<\/p><p>Moreno, M., Benav\u00eddez, U., Carol, H., Rosenkranz, C., Welle, M., Carmona, C., Nieto., A., Chabalgoity, J.A. (2004)\u00a0Local and systemic immune responses to\u00a0<em>Echinococcus granulosus<\/em>\u00a0in experimentally infected dogs.\u00a0Veterinary Parasitology 119, 37-50.<\/p><p>Cancela, M., Carmona, C., Rossi, S., Go\u00f1i, F., Berasain, P. (2004)\u00a0Purification, characterization and immunolocalization of paramyosin from the adult stage of\u00a0<em>Fasciola hepatica<\/em>.\u00a0Parasitology Research 92, 441-448.<\/p><p>Maggioli, G., Piacenza, L., Car\u00e1mbula, B., Carmona, C. (2004)\u00a0Purification and characterisation of a thioredoxin reductase from\u00a0<em>Fasciola hepatica<\/em>.\u00a0Journal of Parasitology 90, 205-211.<\/p><p>Oku, Y., Malgor, R., Benavidez, U., Carmona, C., Kamiya, M. (2004)\u00a0Control program against hydatidosis and the decreased prevalence in Uruguay.\u00a0International Congress Series 1267, 98-104.<\/p><p>Casaravilla, C., Malgor, R., Rossi, A., Sakai, H., Nonaka, N., Kamiya, M., Carmona, C. (2004)\u00a0Production and characterization of monoclonal antibodies against excretory \/ secretory products of adult\u00a0<em>Echinococcus granulosus<\/em>, and their application to coproantigen detection. Parasitology International online.<\/p><p>Casaravilla, C., Malgor, R., Rossi, A., Sakai, H., Nonaka, N., Kamiya, M., Carmona, C. (2005) Production and characterization of monoclonal antibodies against excretory \/ secretory products of adult\u00a0<em>Echinococcus granulosus<\/em>, and their application to coproantigen detection. Parasitology International 54, 43-49.<\/p><p>Ubillos, L., Medeiros, A., Cancela, M., Casaravilla, C., Salda\u00f1a, Y., Dom\u00ednguez, L., Carmona, C., Le Pendu, J., Osinaga, E. (2007) Characterisation of the carcinoma associated Tk antigen in helminth parasites. Experimental Parasitology 116, 129-136.<\/p><p>Rioux, M.C., Carmona, C., Acosta, D., Ward, B., Ndao, M., Gibbs, B., Bennett, H., Spithill, T.W. (2008) Discovery and validation of serum biomarkers expressed over the first twelve weeks of\u00a0<em>Fasciola hepatica<\/em>\u00a0infection in sheep. International Journal for Parasitology 38, 123-136.<\/p><p>Marcilla, A., De la Rubia, J. E., Sotillo, J., Bernal., Carmona, C., Villavicencio, Z., Acosta., D., Tort, J., Bornay, F.J., Esteban, J.G., Toledo, R. (2008) Leucine aminopeptidase is an immunodominant antigen of\u00a0<em>Fasciola hepatica<\/em>\u00a0excretory and secretory products in human infections. Clinical and Vaccine Immunology 15, 95-100.<\/p><p>Acosta, D., Cancela, M., Piacenza, L., Roche, L., Carmona, C., Tort, J. (2008)\u00a0<em>Fasciola hepatica<\/em>\u00a0leucine aminopeptidase, a promising candidate for vaccination against ruminant fasciolosis. Molecular and Biochemical Parasitology 158, 52-64.<\/p><p>Cancela, M., Acosta, D., Rinaldi, G., Silva, E., Duran, R., Roche, L., Zaha, A., Carmona, C., Tort, J. (2008) A distinctive repertoire of cathepsins is expressed by juvenile invasive\u00a0<em>Fasciola hepatica<\/em>. Biochimie 90, 1461-1475.<\/p><p>Cancela, M., Ru\u00e9talo, N., Dell\u00b4Oca, N., da Silva, E., Smircich, P., Rinaldi, G., Roche, L., Carmona, C., Alvarez-Val\u00edn, F., Zaha, A., Tort, J. (2010) Survey of transcrips expressed by the invasive juvenile stage of the trematode\u00a0<em>Fasciola hepatica<\/em>. BMC Genomics 11, 227.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-53b8e93 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"53b8e93\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-20970a9\" data-id=\"20970a9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-eded142 elementor-widget elementor-widget-spacer\" data-id=\"eded142\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Inicio Integrantes Cursos L\u00edneas de Investigaci\u00f3n Proyectos Producci\u00f3n cient\u00edfica Extensi\u00f3n Links de inter\u00e9s Inicio Integrantes Cursos L\u00edneas de Investigaci\u00f3n Proyectos&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-8334","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/higiene.edu.uy\/biologia-parasitaria\/wp-json\/wp\/v2\/pages\/8334","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/higiene.edu.uy\/biologia-parasitaria\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/higiene.edu.uy\/biologia-parasitaria\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/higiene.edu.uy\/biologia-parasitaria\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/higiene.edu.uy\/biologia-parasitaria\/wp-json\/wp\/v2\/comments?post=8334"}],"version-history":[{"count":38,"href":"https:\/\/higiene.edu.uy\/biologia-parasitaria\/wp-json\/wp\/v2\/pages\/8334\/revisions"}],"predecessor-version":[{"id":9051,"href":"https:\/\/higiene.edu.uy\/biologia-parasitaria\/wp-json\/wp\/v2\/pages\/8334\/revisions\/9051"}],"wp:attachment":[{"href":"https:\/\/higiene.edu.uy\/biologia-parasitaria\/wp-json\/wp\/v2\/media?parent=8334"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}